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CNS-5161 hydrochloride

Name: CNS-5161 hydrochloride
Brand: TargetMol
SKU: T10852
Price: 509 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10852Cas No. 160756-38-7

Alias CNS 5161A

CNS-5161 hydrochloride (CNS 5161A) is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.

CNS-5161 hydrochloride

🥰Excellent

Purity: 99.53%

Catalog No. T10852Alias CNS 5161ACas No. 160756-38-7

CNS-5161 hydrochloride (CNS 5161A) is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.

Pack Size	Price	Availability
1 mg	$509	In Stock
5 mg	$1,000	In Stock
10 mg	$1,360	In Stock
25 mg	$2,020	In Stock
50 mg	$2,710	In Stock
1 mL x 10 mM (in DMSO)	$1,150	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.53%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CNS-5161 hydrochloride (CNS 5161A) is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
Targets&IC50	NMDA:1.8 nM (Ki)
In vitro	CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain.
In vivo	In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (i.p.) protects against the necrotic effects of exogenous N-methyl-D-aspartate (ED80: 4 mg/kg). CNS-5161 also demonstrates a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p. and exhibits neuroprotective effects following hypoxic/ischaemic brain injury in neonatal rats[1].
Synonyms	CNS 5161A

Chemical Properties

Molecular Weight	388.38
Formula	C₁₆H₁₉Cl₂N₃S₂
Cas No.	160756-38-7
Smiles	Cl.ClC1=CC=C(SC)C=C1NC(=N)N(C=2C=CC=C(SC)C2)C
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (630.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5748 mL	12.8740 mL	25.7480 mL	128.7399 mL
5 mM	0.5150 mL	2.5748 mL	5.1496 mL	25.7480 mL
10 mM	0.2575 mL	1.2874 mL	2.5748 mL	12.8740 mL
20 mM	0.1287 mL	0.6437 mL	1.2874 mL	6.4370 mL
50 mM	0.0515 mL	0.2575 mL	0.5150 mL	2.5748 mL
100 mM	0.0257 mL	0.1287 mL	0.2575 mL	1.2874 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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